An Improved Implementation of Codon Adaptation Index
نویسندگان
چکیده
منابع مشابه
An Improved Implementation of Codon Adaptation Index
Codon adaptation index is a widely used index for characterizing gene expression in general and translation efficiency in particular. Current computational implementations have a number of problems leading to various systematic biases. I illustrate these problems and provide a better computer implementation to solve these problems. The improved CAI can predict protein production better than CAI...
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15 صفحه اولRelative Codon Adaptation: A Generic Codon Bias Index for Prediction of Gene Expression
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We propose a simple, sensitive measure of synonymous codon usage bias, the Relative Codon Adaptation Index (rCAI), as a way to discriminate better between highly biased and unbiased regions, compared with the widely used Codon Adaptation Index (CAI). CAI is a geometric mean of the relative usage of codons in a gene, and is calculated using the codon usage table trained with a set of highly expr...
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ژورنال
عنوان ژورنال: Evolutionary Bioinformatics
سال: 2007
ISSN: 1176-9343,1176-9343
DOI: 10.1177/117693430700300028